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Sister Chromatids Vs Non-Sister Chromatids: Key Differences & Functions

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Introduction: Understanding Chromatids and Their Role in Cell Division

Our body is made up of cells, and inside each cell, the nucleus contains chromosomes that store DNA—the genetic material of life. Chromosomes duplicate before cell division, forming two identical halves called chromatids.


During cell division, two types of chromatids are involved:
 

  • Sister chromatids – Genetically identical chromatids formed by DNA replication.

  • Non-sister chromatids – Chromatids from homologous chromosomes that participate in genetic recombination during meiosis.


In this article, we will explore the differences between sister chromatids and non-sister chromatids, their functions, and their role in genetic inheritance.


Key Differences Between Sister Chromatids and Non-Sister Chromatids

Feature

Sister Chromatids

Non-Sister Chromatids

Origin

Created by DNA replication of a single chromosome

Belong to homologous chromosomes from different parents

Genetic Composition

Identical (same alleles)

Different (contain different alleles)

Connection

Attached at the centromere

Form a chiasma during meiosis

Formation Phase

Created in S-phase of interphase

Appear during Metaphase I of meiosis

Function

Ensure accurate chromosome distribution

Allow genetic recombination and variation

Type of Reproduction

Asexual reproduction (mitosis)

Sexual reproduction (meiosis)


Essential Study Materials for NEET UG Success

FAQs on Sister Chromatids Vs Non-Sister Chromatids: Key Differences & Functions

1. How do sister chromatids differ from non-sister chromatids?

Sister chromatids are identical copies of a chromosome, whereas non-sister chromatids belong to homologous chromosomes and contain different genetic information.

2. What is the function of sister chromatids?

Sister chromatids ensure accurate DNA replication and equal chromosome distribution during cell division.

3. How do non-sister chromatids contribute to genetic variation?

Non-sister chromatids exchange genetic material during crossing over, creating new gene combinations in offspring.

4. Why do non-sister chromatids form chiasmata?

Chiasmata form during meiosis I, allowing genetic recombination between homologous chromosomes.

5. When do sister chromatids separate?

Sister chromatids separate during anaphase of mitosis and anaphase II of meiosis.

6. What is the difference between homologous chromosomes and sister chromatids?

Homologous chromosomes come from both parents and contain different genetic information, while sister chromatids are identical copies of the same chromosome.

7. Can sister chromatids have different alleles?

Normally, sister chromatids are identical, but mutations can cause differences, making them heterozygous.

8. What role do sister chromatids play in mitosis?

They ensure that each daughter cell receives an exact copy of DNA.

9. Do all organisms have sister chromatids?

Yes, all eukaryotic organisms with chromosomes undergo DNA replication, forming sister chromatids.

10. Why are non-sister chromatids important in meiosis?

They allow for genetic recombination, leading to variation in offspring.