Question

From a heredity point of view, which marriage is not suitable?
A. Man Rh (\[-\]) and Woman Rh (\[+\])
B. Both Rh (\[+\])
C. Both Rh (\[-\])
D. Man Rh (\[+\]) and Woman Rh (\[-\])

Answer 1

Hint: The idea of unsuitable marriage from the point of view of blood group was suggested for the very first time by Karl Landsteiner and A.S. Weiner in 1940. The defense mechanism that can end up damaging the infant during the second pregnancy can be triggered and is called erythroblastosis fetalis.

Complete answer: Marriage between an Rh-positive man and an Rh-negative woman is not ideal from a genetic point of view. This results in Rh antigens from the foetus acting as alien invaders in the body of the mother. This initiates the protective mechanism that during the second pregnancy will harm the foetus. This is known as erythroblastosis foetalis.
Additional Information:
A method is known as the Rh blood group system for classifying blood groups according to the presence or absence of the Rh antigen. On the cell membranes of red blood cells, the Rh factor exists (erythrocytes). In the basic test for determining the presence of Rh antigen in human blood, Rh is obtained by using the blood of rhesus monkeys. Several separate Rh antigens have since been identified. RhD triggers the most extreme immune reaction and is the primary determinant of the Rh trait.
Thus, the correct response is Man RN (\[+\]) and Woman Rh (\[-\]), i.e., Option D

Note: The Rh-positive offspring of Rh-incompatible parents during pregnancy (when the mother is Rh-negative and the father is Rh-positive). Unless the mother has developed anti-Rh antibodies, the first child is in no danger. One or more exchange transfusions are involved in its treatment. It can be prevented by vaccinating the mother after the birth of her firstborn with Rh immunoglobulin. Before the mother's immune system may produce antibodies, the vaccine kills any foetal blood cells.