Mitochondria play a vital role in the life of eukaryotic cells. Known popularly as the powerhouses of the cell, these rod-shaped organelles generate adenosine triphosphate (ATP), the main energy currency. They also take part in processes like cellular respiration, cell growth, and many other essential activities. Understanding the structure, and function of mitochondria can help you learn this crucial topic in biology.
Mitochondria are double-membraned, rod-shaped organelles found in the cytoplasm of most eukaryotic cells. The singular term ‘mitochondrion’ comes from Greek words meaning “thread” and “granule.” These organelles were first described by the German pathologist Richard Altmann in 1890.
They are present in both plant cells and animal cells.
They are crucial for cellular respiration, differentiation, cell signalling, and controlling the cell cycle.
They have their genetic material (mitochondrial DNA) and ribosomes.
They produce ATP, which powers various biological processes.
Matrix
The matrix is the viscous fluid enclosed by the inner membrane.
It contains enzymes for oxidative phosphorylation, ribosomes, mitochondrial DNA, ions, and other molecules.
It plays a key role in the Krebs cycle and in generating molecules that feed into ATP production.
Cristae
Cristae are the folds of the inner membrane that project into the matrix.
These folds greatly increase the surface area, enabling enhanced ATP production during cellular respiration.
Ribosomes
Mitochondrial ribosomes (mitoribosomes) synthesise some of the proteins needed by mitochondria.
They translate specific mRNAs encoded by the mitochondrial DNA.
Inner Membrane
The inner membrane contains several unique transporter proteins.
It is selectively permeable, which means it carefully regulates molecules entering or leaving the mitochondrial matrix.
Outer Membrane
The outer membrane contains proteins called porins, forming channels that allow smaller molecules to pass into the intermembrane space.
It also houses enzymes that help in various metabolic and signalling functions.
Intermembrane Space
This is the region between the inner and outer membranes.
It can be further divided into the intra-cristae space and the lumen, which are separated by narrow openings known as cristae junctions (10 to 40 nm in diameter).
It is important in protein transport, protein modification, and in regulating apoptosis (programmed cell death).
ATP Production: Mitochondria generate ATP through oxidative phosphorylation, a process that occurs along the inner membrane.
Cellular Respiration: They utilise oxygen to convert nutrients into energy.
Metabolic Activities: Mitochondria are involved in various metabolic pathways, including the Krebs cycle.
Cell Signalling: They help regulate calcium levels and influence signalling cascades that control cell growth.
Apoptosis: Mitochondria release factors that initiate programmed cell death, maintaining tissue health by removing damaged cells.
These roles underscore why these organelles are often called the “powerhouses” of the cell.
Test your understanding with these simple questions:
1. Which membrane of the mitochondria is folded to form cristae?
a) Outer membrane
b) Inner membrane
c) Intermembrane space
d) Matrix
Answer: b) Inner membrane
2. What is the main function of mitochondria?
a) Production of proteins
b) Storage of genetic material
c) ATP production
d) Cell wall formation
Answer: c) ATP production
3. Who first described mitochondria?
a) Gregor Mendel
b) Richard Altmann
c) Louis Pasteur
d) James Watson
Answer: b) Richard Altmann
1. Why are mitochondria often called the 'powerhouse of the cell'?
Mitochondria are called the powerhouse because they are the primary site of cellular respiration. In this process, they convert nutrients like glucose into ATP (adenosine triphosphate), which is the main energy currency that fuels nearly all of the cell's activities.
2. What are the key parts to label in a diagram of a mitochondrion?
When drawing a mitochondrion, the most important parts to label are:
3. How does the folded inner membrane of a mitochondrion help it produce more energy?
The inner membrane's folds, known as cristae, drastically increase its total surface area. This extra space allows the mitochondrion to hold many more proteins and enzymes required for making ATP. A larger surface area means more reactions can happen at once, making energy production far more efficient.
4. Why do mitochondria have their own DNA, separate from the cell's nucleus?
Mitochondria possess their own DNA due to the endosymbiotic theory. This theory suggests that mitochondria were once independent, free-living bacteria that were engulfed by a larger host cell. This unique DNA allows them to create some of their own proteins and replicate on their own when the cell needs more energy.
5. Are mitochondria found in plant cells as well as animal cells?
Yes, mitochondria are found in almost all eukaryotic cells, including both plant and animal cells. While plants use chloroplasts for photosynthesis to create food, they still rely on mitochondria to break down that food to release usable energy (ATP) for their own cellular functions.
6. Why would a muscle cell have many more mitochondria than a skin cell?
The number of mitochondria in a cell is directly related to its energy demand. Muscle cells are extremely active and need a constant, large supply of ATP to contract and move. Skin cells, in contrast, have much lower energy requirements. As a result, muscle cells are packed with thousands of mitochondria to meet this high demand, while skin cells have far fewer.
7. Besides generating energy, what is another crucial role of mitochondria in a cell?
Beyond energy production, mitochondria are essential for regulating programmed cell death, a process called apoptosis. They can release specific molecules, like cytochrome c, that initiate a chain reaction leading to the cell's self-destruction. This process is vital for removing old, damaged, or unnecessary cells from the body.
8. What are the essential steps to draw a clear and well-labelled diagram of a mitochondrion?
To draw an easy and accurate diagram, follow these steps: